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[Digestive manifestations in systemic sclerosis].

¹Service d'Hépato-Gastroentérologie et d'Assistance Nutritive, Hôpital Lariboisière, 2, rue Ambroise-Paré, 75475 Paris Cedex 10, France. alain.attar@avc.ap-hop-paris.fr

Annales De Medecine Interne

|September 10, 2002

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Systemic sclerosis frequently causes gastrointestinal issues like reflux and motility problems. Effective treatments include proton pump inhibitors for reflux and prokinetic agents for pseudo-obstruction.

Area of Science:

Gastroenterology
Rheumatology
Pathology

Context:

Systemic sclerosis (SSc) commonly affects the gastrointestinal (GI) tract.
GI manifestations in SSc are often the earliest signs, preceding other organ involvement.
Pathology involves vasculopathy, leading to ischemia, dysfunction, and fibrosis.

Purpose:

To summarize the common gastrointestinal manifestations in systemic sclerosis.
To highlight the impact of these manifestations on patient health.
To review current treatment strategies for GI symptoms in SSc.

Summary:

About 80% of SSc patients experience digestive issues, including gastroesophageal reflux, intestinal motility abnormalities (chronic intestinal pseudo-obstruction), small bowel bacterial overgrowth, and malnutrition.

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Vasculopathy is the underlying pathology, causing tissue ischemia and progressive organ damage.

High-dose proton pump inhibitors are safe and effective for reflux symptom relief and preventing complications.

Prokinetic agents like metoclopramide, domperidone, octreotide, and erythromycin are used for pseudo-obstruction.

Impact:

Improved understanding of SSc's GI impact.
Guidance on managing common and debilitating GI symptoms in SSc patients.
Highlights the importance of early diagnosis and comprehensive management of GI involvement in SSc.