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[Microchimerisme in systemic sclerosis].

Sélim Aractingi1, Stéphanie Regnier

  • 1Unité de Dermatologie, Hôpital Tenon, 4, rue de la Chine, 75020 Paris, France.

Annales De Medecine Interne
|September 10, 2002
PubMed
Summary
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Systemic sclerosis (SSc) may involve fetal cells, but its role is complex. This review examines microchimerism in SSc, considering its potential multistep process.

Area of Science:

  • Immunology
  • Genetics
  • Rheumatology

Context:

  • Systemic sclerosis (SSc) is an autoimmune disease.
  • Fetal cells in maternal circulation (microchimerism) are observed in some SSc patients.
  • The role of microchimerism in SSc pathogenesis is debated.

Purpose:

  • To review recent literature on microchimerism in systemic sclerosis.
  • To evaluate the evidence supporting microchimerism as a factor in SSc development.
  • To explore the potential of microchimerism in a multistep SSc process.

Summary:

  • Association between fetal cells and SSc suggests an allogeneic fetomaternal reaction hypothesis.
  • Microchimerism is also present in healthy females, complicating the SSc link.
  • Differences exist between SSc and graft-versus-host reactions, suggesting microchimerism is one step in SSc.

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Impact:

  • Highlights the complex role of microchimerism in autoimmune diseases.
  • Provides insights into potential diagnostic or therapeutic targets for SSc.
  • Encourages further research into the multistep pathogenesis of systemic sclerosis.