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[Scleroderma and pregnancy].

Monsef Rabhi1, Kiet Phuong Tiev, Thierry Genereau

  • 1Service de Médecine Interne, Hôpital Saint-Antoine, 184, rue du Faubourg-Saint-Antoine, 75571 Paris Cedex 12, France.

Annales De Medecine Interne
|September 10, 2002
PubMed
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Pregnancy in women with scleroderma (a rare connective-tissue disease) does not increase infertility but carries risks like renal crisis and premature birth due to placental issues. Careful planning and multidisciplinary care are key.

Area of Science:

  • Rheumatology
  • Obstetrics
  • Immunology

Background:

  • Scleroderma is a rare connective-tissue disease with symptom onset typically in the early 40s, making concurrent pregnancies infrequent.
  • Understanding the interplay between scleroderma and pregnancy is crucial for managing patient care.

Purpose of the Study:

  • To review the reciprocal influences of pregnancy and scleroderma.
  • To outline current knowledge and key management strategies for pregnant patients with scleroderma.

Main Methods:

  • This is a review article, synthesizing existing knowledge on scleroderma and pregnancy.
  • Key points are derived from current literature and clinical experience.

Main Results:

  • Pregnancy does not increase infertility in women with scleroderma.

Related Experiment Videos

  • Pregnancy poses a higher risk of renal crisis, particularly in active, diffuse scleroderma.
  • Scleroderma can cause placental vascular abnormalities, leading to prematurity and small for gestational age infants.
  • There is no increased risk of miscarriage or spontaneous abortion.
  • Pregnant patients with scleroderma present anesthetic challenges due to physical and visceral involvement.

    • Conclusions:

    • Pregnancy planning and multidisciplinary high-risk pregnancy management are essential for successful outcomes.
    • Future research should explore microchimerism in scleroderma and placental findings to improve obstetrical prognosis.