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Hemostatic and inflammatory markers in obese youths: effects of exercise and adiposity
Paule Barbeau1, Mark S Litaker, Kristy F Woods
1Georgia Prevention Institute, Department of Pediatrics, Augusta 30912, USA.
Objectives:
To determine the relation of hemostatic markers to cardiovascular fitness and adiposity and the effect of physical training (PT) on these markers.
Study Design:
Seventy-four obese teenagers were randomly assigned to 8 months of lifestyle education (LSE), LSE plus moderate-intensity PT, or LSE plus high-intensity PT. Measures included fibrinogen, plasminogen activator inhibitor-1 (PAI-1), D-dimer, C-reactive protein (CRP), fitness, percent body fat (%BF), and visceral adiposity (VAT).
Results:
At baseline, fibrinogen and CRP were significantly correlated with %BF and VAT (0.27
Conclusions:
Unfavorable levels of fitness and adiposity were associated with higher levels of hemostatic markers, putting individuals with this profile at greater risk for future cardiovascular disease. No evidence was provided that 8 months of PT had a direct influence on these markers in obese youths.
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