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HLA in Egyptian children with biliary atresia
Hassan H A-Kader1, Moustafa El-Ayyouti, Samia Hawas
1Department of Pediatrics, Upstate Medical University, Syracuse, New York 13210, USA.
The Journal of Pediatrics
|September 10, 2002
Abstract:
We studied the human leukocytes antigens in 18 Egyptian children with biliary atresia (BA) without extrahepatic congenital malformations. There was a significant increased frequency of both B8 and DR3 (83.3% and 94.4% in patients with BA compared with 6.5% and 14.9% in the general population, respectively). Ten patients had the B8/DR3 haplotype. Our results support the hypothesis that genetic factors may play a role in susceptibility to BA.