Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Detecting Repetitive DNA in Eukaryotes.

Jie Chen1, Da-Fu Ding

  • 1Shanghai Institute of Biochemistry, the Chinese Academy of Sciences, Shanghai 200031, China.

Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica Et Biophysica Sinica
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Determination of endosulfan residues in eel using GC].

Se pu = Chinese journal of chromatography·2008
Same author

A new serum cystatin C-based equation for assessing glomerular filtration rate in liver transplantation.

Clinical chemistry and laboratory medicine·2008
Same author

Characterization of specific egg yolk immunoglobulin (IgY) against mastitis-causing Escherichia coli.

Veterinary microbiology·2008
Same author

Mixed macromolecular crowding inhibits amyloid formation of hen egg white lysozyme.

Biochimica et biophysica acta·2008
Same author

A pharmacogenetic study of pregnane X receptor (NR1I2) in Han Chinese.

Current drug metabolism·2008
Same author

Chronic nickel-induced DNA damage and cell death: the protection role of ascorbic acid.

Environmental toxicology·2008
Same journal

[Prokaryotic expression and characterization of rice Rac protein osRACB].

Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica·2003
Same journal

[Purification of a big defensin from Ruditapes philippinesis and its antibacterial activity].

Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica·2003
Same journal

[Expression, purification and identification of recombinant SARS coronavirus membrane protein].

Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica·2003
Same journal

[Molecular cloning of mTSARG3 gene related to apoptosis in mouse spermatogenic cells].

Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica·2003
Same journal

[The immunopotentiation of human B lymphocyte stimulator C-terminal peptide].

Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica·2003
Same journal

[Cloning, eukaryotic expression and function assay of recombinant leukemia inhibitory factor gene LIF].

Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica·2003
See all related articles

A new software identifies repetitive elements, particularly Alu sequences, with high accuracy. This tool aids in recognizing repeat elements within genetic sequences, improving genomic analysis.

Area of Science:

  • Bioinformatics
  • Genomics
  • Computational Biology

Background:

  • Repetitive elements, such as Alu sequences, are abundant in genomes and play roles in genomic structure and evolution.
  • Accurate detection of these elements is crucial for understanding genome organization and function.

Purpose of the Study:

  • To develop and validate a novel software tool for the detection of repetitive elements, with a specific focus on Alu sequences.
  • To assess the software's performance using correspondence analysis theory.

Main Methods:

  • The software was designed based on correspondence analysis principles.
  • Performance was evaluated on a test set comprising 38 gene sequences.
  • The software's ability to identify Alu elements within coding regions and large-scale sequences was also tested.

Related Experiment Videos

Main Results:

  • The software demonstrated a true-negative rate of approximately 5.8% and a false-positive rate of about 4.8% on the test set.
  • The software successfully identified Alu elements spliced into coding regions.
  • Successful detection of Alu elements within large-scale T-cell receptor loci sequences was achieved.

Conclusions:

  • The developed software is an effective tool for recognizing repetitive elements, especially Alu sequences.
  • The software's accuracy and capabilities make it valuable for genomic sequence analysis.
  • This tool enhances the ability to study the distribution and impact of repetitive elements in genomes.