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Tei-Index in coronary artery disease--validation in patients with overall cardiac and isolated diastolic dysfunction

C Bruch1, A Schmermund, N Dagres

  • 1Innere Medizin C Albert-Schweitzer-Str. 33 48129 Münster, Germany. bruchc@uni-muenster.de

Zeitschrift Fur Kardiologie
|September 11, 2002
PubMed

Insights

The Tei-Index effectively identifies overall cardiac dysfunction in coronary artery disease (CAD) patients. However, its utility is limited for diagnosing primary diastolic dysfunction in CAD.

Area of Science:

  • Cardiology
  • Cardiac Physiology
  • Diagnostic Imaging

Background:

  • The Tei-Index, a ratio of cardiac mechanical times, is established for assessing disease severity in conditions like dilated cardiomyopathy.
  • Its diagnostic value in coronary artery disease (CAD) remains uncertain.
  • This study aimed to validate the Tei-Index in CAD patients with varying degrees of cardiac dysfunction.

Purpose of the Study:

  • To validate the Tei-Index for diagnosing cardiac dysfunction in patients with coronary artery disease (CAD).
  • To assess the Tei-Index's effectiveness in differentiating overall cardiac dysfunction from isolated diastolic dysfunction in CAD.

Main Methods:

  • Sixty subjects underwent left heart catheterization and echocardiography.
  • Patients were categorized into overall cardiac dysfunction (OCD), isolated diastolic dysfunction (IDD), and control groups.
  • The Tei-Index was calculated using Doppler echocardiography.

Main Results:

  • The Tei-Index was easily and reproducibly measured in all participants.
  • Significantly elevated Tei-Index in OCD patients compared to controls (0.71 vs. 0.40, p < 0.01).
  • Largely unchanged Tei-Index in IDD patients compared to controls (0.45 vs. 0.40, p = ns).
  • Receiver operating characteristic analysis showed high accuracy (AUC 0.92) for identifying OCD using a cutoff of 0.49 (96% sensitivity, 86% specificity).

Conclusions:

  • The Tei-Index is a valid and easily obtainable indicator of global cardiac dysfunction in CAD patients with impaired systolic and diastolic function.
  • The Tei-Index demonstrates limited utility in patients with primary diastolic dysfunction in CAD.
Abstract

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