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Related Experiment Videos

Stereocomplexes based on poly(lactic acid) and insulin: formulation and release studies.

J Slager1, A J Domb

  • 1Department of Chemical Engineering, Rice University, Houston, TX 77005-1892, USA.

Biomaterials
|September 11, 2002
PubMed
Summary
This summary is machine-generated.

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New insulin complexes with D-poly(lactic acid) (D-PLA) form microparticulates for sustained release. Stereospecific complexation indicates potential for advanced peptide and protein delivery systems.

Area of Science:

  • Polymer Science
  • Biomaterials Science
  • Drug Delivery Systems

Background:

  • Insulin delivery systems require controlled release mechanisms.
  • Poly(lactic acid) (PLA) is a biodegradable polymer with potential in drug encapsulation.
  • Stereochemistry of polymers can influence complex formation and properties.

Purpose of the Study:

  • To investigate the formation of complexes between insulin and poly(lactic acid) (PLA).
  • To explore the potential of these complexes as a controlled release system for insulin.
  • To determine the role of stereochemistry in complex formation.

Main Methods:

  • Mixing insulin with D-poly(lactic acid) (D-PLA) in acetonitrile solution.
  • Characterizing the microparticulate precipitate formed.

Related Experiment Videos

  • Assessing insulin release from the microparticulates in a buffer solution.
  • Investigating complex formation with L-PLA and D,L-PLA.

    • Main Results:

    • Spontaneous formation of insulin-D-PLA microparticulate complexes.
    • Complexes exhibited a porous structure, insolubility in common solvents, and a unique transition temperature.
    • Sustained insulin release observed over several weeks from the microparticulates.
    • Stereospecific complexation demonstrated, with L-PLA or D,L-PLA not forming precipitates with insulin alone.
    • Addition of L-PLA to insulin-D-PLA solutions resulted in D-PLA-insulin and D-PLA-L-PLA complexes.

    Conclusions:

    • Diastereoisomeric and stereocomplexes of insulin with PLA can be formed.
    • The stereospecific nature of complexation is crucial for precipitate formation.
    • These macromolecular stereocomplexes represent a novel approach for developing next-generation controlled release systems for peptides and proteins.