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Related Experiment Videos

Clozapine intoxication in a dog.

Boel A Fransson1, Katrina A Mealey, Sarah R Dutta

  • 1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman 99164-7060, USA.

Journal of the American Animal Hospital Association
|September 11, 2002
PubMed
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Clozapine intoxication in a dog was confirmed by decreasing serum drug levels. This case highlights the importance of monitoring clozapine levels in pets to ensure successful treatment outcomes.

Area of Science:

  • Veterinary Toxicology
  • Pharmacology

Background:

  • Clozapine, a tricyclic dibenzodiazepine, is used for schizophrenia in humans.
  • Human intoxication signs include tachycardia, seizures, agitation, and sialorrhea.

Observation:

  • A dog presented with suspected clozapine intoxication.
  • Clinical signs observed were ptyalism, hyperthermia, tachycardia, and hypersensitivity to stimuli.

Findings:

  • Serum clozapine levels were monitored, confirming intoxication.
  • Peak concentration was ~6,000 ng/mL with a 5-hour elimination half-life.

Implications:

  • This case demonstrates the successful management of clozapine toxicity in a canine patient.
  • Highlights the need for veterinary awareness of clozapine's toxic potential in pets.

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