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Related Experiment Videos

Immunity to Streptococcus equi.

J B Woolcock

    Australian Veterinary Journal
    |December 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Horses vaccinated against Strangles (Str. equi) showed strong antibody responses, but these declined within a year, necessitating annual boosters. Natural infection provided less durable immunity.

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    Area of Science:

    • Veterinary Immunology
    • Equine Infectious Diseases

    Background:

    • Strangles (Streptococcus equi) is a significant equine respiratory disease.
    • Understanding the immune response to Strangles vaccination and natural infection is crucial for disease control.

    Purpose of the Study:

    • To evaluate the antibody development and immune response in horses following vaccination against Strangles.
    • To compare the immune response after vaccination with that following natural Strangles infection.

    Main Methods:

    • Utilized the long chain test and bactericidal test to measure antibody levels.
    • Monitored antibody titres in horses after a 3-dose vaccination course.
    • Compared immune responses in vaccinated horses with those from animals recovering from natural Strangles outbreaks.

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    Main Results:

    • A full 3-dose vaccination course induced satisfactory antibody titres (long chain index > 5.0) and bactericidal capacity.
    • Antibody titres declined within 12 months post-vaccination.
    • Horses recovering from natural infection showed declining antibody levels by 9 weeks, indicating limited long-term immunity.
    • Vaccination reactions were noted in horses with high pre-existing antibody titres.

    Conclusions:

    • Annual booster vaccinations are recommended to maintain protective antibody levels against Strangles.
    • Natural Strangles infection does not appear to confer long-lasting immunity.
    • High initial antibody titres may be associated with vaccination reactions.