Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mouse-specific immunocontraceptive polyepitope vaccines.

C M Hardy1, J Pekin, J ten Have

  • 1Pest Animal Control Cooperative Research Centre, CSIRO Sustainable Ecosystems, Canberra, ACT, Australia. chris.hardy@csiro.au

Reproduction (Cambridge, England). Supplement
|September 11, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Vacuum Cherenkov Detector (VCD) for γ-ray measurements in inertial confinement fusion experiments.

The Review of scientific instruments·2022
Same author

Upgrade of the gated laser entrance hole imager G-LEH-2 on the National Ignition Facility.

The Review of scientific instruments·2021
Same author

Perspectives on the clonal persistence of presumed 'ghost' genomes in unisexual or allopolyploid taxa arising via hybridization.

Scientific reports·2019
Same author

Weight loss and improved metabolic outcomes amongst rural African American women in the Deep South: six-month outcomes from a community-based randomized trial.

Journal of internal medicine·2017
Same author

Observation of hohlraum-wall motion with spectrally selective x-ray imaging at the National Ignition Facility.

The Review of scientific instruments·2016
Same author

Taxonomic revision of Phascogale tapoatafa (Meyer, 1793) (Dasyuridae; Marsupialia), including descriptions of two new subspecies and confirmation of P. pirata Thomas, 1904 as a 'Top End' endemic.

Zootaxa·2015
Same journal

Reproduction in domestic ruminants V. Overview.

Reproduction (Cambridge, England). Supplement·2003
Same journal

Gene targeting in livestock.

Reproduction (Cambridge, England). Supplement·2003
Same journal

Reprogramming the genome: role of the cell cycle.

Reproduction (Cambridge, England). Supplement·2003
Same journal

The differential secretion of FSH and LH: regulation through genes, feedback and packaging.

Reproduction (Cambridge, England). Supplement·2003
Same journal

Growth and maturation of oocytes in vitro.

Reproduction (Cambridge, England). Supplement·2003
Same journal

Domestic ruminants as models for the elucidation of the mechanisms controlling ovarian follicle development in humans.

Reproduction (Cambridge, England). Supplement·2003
See all related articles

A novel mouse-specific anti-fertility vaccine candidate significantly reduced mouse fertility by over 40%. This polyepitope antigen shows promise for controlling invasive mouse populations.

Area of Science:

  • Immunology
  • Reproductive Biology
  • Vaccine Development

Background:

  • Developing targeted anti-fertility strategies is crucial for invasive species control.
  • Mouse fertility antigens offer potential targets for immunocontraception.

Purpose of the Study:

  • To produce and assess mouse-specific polyepitope protein antigens for their anti-fertility effects.
  • To evaluate a novel antigen construct as a potential anti-fertility vaccine for mouse population control.

Main Methods:

  • Produced recombinant polyepitope antigens fused to maltose binding protein (MBP) in bacterial systems.
  • Immunized female BALB/c mice with antigen constructs, MBP only, or PBS.
  • Assessed fertility reduction and viable embryo counts in immunized mice.

Related Experiment Videos

Main Results:

  • One antigen construct (MBP-polyepitope B) significantly reduced mouse fertility by over 40%.
  • The number of viable embryos decreased by more than 60% in the treated group.
  • This construct targets mouse fertility antigens ZP1, ZP3, SP56, and proliferin.

Conclusions:

  • The MBP-polyepitope B antigen demonstrates significant anti-fertility effects in mice.
  • This antigen is a promising candidate for a mouse-specific anti-fertility vaccine.
  • Further development using recombinant murine cytomegalovirus is planned for field application.