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Effects of chronic inflammatory bowel diseases on left ventricular structure and function: a study protocol.
Ugo Cioffi1, Michele M Ciulla, Matilde De Simone
1Department of Surgery, University of Milan, Ospedale Maggiore di Milano-IRCCS, Via F Sforza, 35-20122, Milano, Italy. ugo.cioffi@unimi.it
BMC Public Health
|September 11, 2002
Summary
Inflammatory bowel diseases (IBD) may increase collagen deposition, potentially affecting heart structure. This study investigates cardiac collagen metabolism and function in IBD patients before and after surgery.
Area of Science:
- Cardiovascular Medicine
- Gastroenterology
- Biochemistry
Background:
- Increased collagen deposition, particularly types I, III, and V, is observed in inflammatory bowel diseases (IBD), contributing to intestinal fibrosis.
- Limited data exists on collagen deposition outside the primary affected organs in IBD.
- Chronic inflammation in IBD may influence systemic collagen metabolism and cardiac structure.
Purpose of the Study:
- To evaluate the impact of IBD on left ventricular structure and function.
- To assess splanchnic and systemic collagen metabolism and deposition in IBD patients.
- To investigate the relationship between disease duration, inflammation, and cardiac alterations.
Main Methods:
- Study includes 30 active IBD patients (15 Crohn's, 15 Ulcerative Colitis) and 15 healthy controls.
- Patients are studied pre-surgery and at 6 and 12 months post-surgery.
- Assessments include blood samples for collagen metabolism (procollagen III assay) and transthoracic echocardiography for cardiac function and collagen deposition.
Main Results:
- Data collection ongoing; results not yet available.
Conclusions:
- This study aims to provide insights into the association between IBD and cardiovascular disorders.
- It seeks to determine if chronic inflammation and altered collagen metabolism affect left ventricular structure and function in IBD patients.
- Findings may correlate cardiac changes with the duration of IBD.