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Correlation between cellular localization of TEL/AML1 fusion protein and repression of AML1-mediated transactivation

Jae Kyun Rho1, Jae Hyun Kim, Jiyeon Yu

  • 1Department of Biology, School of Life Sciences, Research Center for Bioresource and Health, Chungbuk National University Cheongju, 361-764, Chungbuk, Republic of Korea.

Biochemical and Biophysical Research Communications
|September 11, 2002
PubMed

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Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...