Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fos immunoreactivity in rat subcortical visual shell in response to illuminance changes.

J R Prichard1, R T Stoffel, D L Quimby

  • 1Neuroscience Training Program, University of Wisconsin-Madison, 1300 University Avenue, Madison, WI 53706, USA.

Neuroscience
|September 11, 2002
PubMed
Summary

The study shows specific brain regions in the pretectum and lateral geniculate complex activate in response to light, indicating their role in visual processing and circadian rhythms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of oral temazepam on slow waves during non-rapid eye movement sleep in healthy young adults: A high-density EEG investigation.

International journal of psychophysiology : official journal of the International Organization of Psychophysiology·2016
Same author

Effects of oral temazepam on sleep spindles during non-rapid eye movement sleep: A high-density EEG investigation.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2015
Same author

Immunohistochemistry for CDX2 expression in non-goblet-cell Barrett's oesophagus.

British journal of biomedical science·2014
Same author

Altered overnight modulation of spontaneous waking EEG reflects altered sleep homeostasis in major depressive disorder: a high-density EEG investigation.

Journal of affective disorders·2013
Same author

Topographic and sex-related differences in sleep spindles in major depressive disorder: a high-density EEG investigation.

Journal of affective disorders·2012
Same author

Overnight changes in waking auditory evoked potential amplitude reflect altered sleep homeostasis in major depression.

Acta psychiatrica Scandinavica·2011

Area of Science:

  • Neuroscience
  • Circadian Biology
  • Visual System Research

Background:

  • Immediate early gene expression, like c-fos, is a key marker for neural activity in the circadian visual system.
  • The pretectum is increasingly recognized for its role in regulating sleep and circadian responses to light.
  • Previous research indicates pretectal lesions disrupt sleep and circadian rhythms in response to light changes.

Purpose of the Study:

  • To investigate light-induced Fos expression in specific pretectal nuclei.
  • To determine if these responses are region-specific and sensitive to the timing of light exposure.
  • To elucidate the role of the pretectum in processing visual information related to circadian regulation.

Main Methods:

  • Utilized immunocytochemistry to visualize Fos expression, a marker for neuronal activation.

Related Experiment Videos

  • Subjected rats to controlled light-to-dark and dark-to-light shifts at midday and midnight.
  • Quantified Fos activation in pretectal and lateral geniculate nuclei using automated scoring.

    • Main Results:

    • Identified significant Fos activation in three pretectal regions (olivary pretectal nucleus, posterior limitans, commissural pretectal nucleus homolog) and two lateral geniculate regions (intergeniculate leaflet, ventral lateral geniculate nucleus).
    • Observed preferential Fos activation in the olivary pretectal nucleus, posterior limitans, and ventral lateral geniculate nucleus following acute light onset versus chronic light exposure at midday.
    • Found that at midnight, these nuclei showed Fos activation in response to both chronic light exposure and acute light onset.

    Conclusions:

    • The pretectum, particularly the olivary pretectal nucleus, posterior limitans, and ventral lateral geniculate nucleus, exhibits robust, region-specific responses to light.
    • These findings support the hypothesis that pretectal nuclei are crucial integrators of light information.
    • The pretectum likely plays a significant role in coordinating behavioral and physiological responses to changes in illumination and circadian timing.