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Published on: March 25, 2015
Chitosan and its derivatives--a promising non-viral vector for gene transfection
1Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, China. wenguangliu@sina.com
Abstract:
The ability of a vector to ferry gene into targeted cells is the premise of improving gene-transfer efficiency. Chitosan, a naturally occurring cationic polysaccharide, has been shown to excel in transcellular transport. This attribute has been fully reflected in chitosan-mediated gene transfection systems. The objective of this review is to summarize the recent encouraging advances in unveiling the mechanism of cell entry and application of chitosan and its derivatives as novel non-viral vectors. It is our belief that researchers will uncover more truth about chitosan-based vector and realize the long-term goal of gene transfection--produce the desired clinical effect.
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