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Related Experiment Videos

A double coil chromatin sub-unit model.

S Bram

    Biochimie
    |November 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    A novel double-coil DNA model in chromatin sub-units reveals a compact structure of approximately 200 base pairs. This chromatin structure model explains DNA digestion fragments and compaction ratios.

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    Area of Science:

    • Molecular Biology
    • Structural Biology
    • Biophysics

    Background:

    • Chromatin structure is fundamental to DNA packaging and regulation.
    • Previous models have not fully explained observed DNA compaction and fragmentation patterns.

    Purpose of the Study:

    • To propose a new structural model for DNA within chromatin sub-units.
    • To reconcile existing biochemical and biophysical data with structural observations.

    Main Methods:

    • Freeze-fracture electron microscopy of chromatin replicas.
    • X-ray and neutron scattering analyses.
    • Analysis of DNA digestion fragment sizes.

    Main Results:

    • A double-coil DNA model for chromatin sub-units was proposed.

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  • The model features an inner coil (70 A diameter) and an outer coil (150 A diameter).
  • Each sub-unit contains approximately 200 base pairs with a contour length of 600-700 A.

    • Conclusions:

    • The proposed double-coil model is consistent with biochemical and biophysical data.
    • It readily explains 200 and 100 base pair DNA fragments and a 6:1 DNA compaction.
    • The model suggests specific histone associations with inner and outer coils.