Asthma pathophysiology and the scientific rationale for combination therapy
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Updated: Sep 29, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
1Division of Allergy and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Abstract:
The clinical and scientific description of asthma has been undergoing an evolution of continuous revision during the past 10 years. This disorder has been recognized as a complex entity with interplay between genetic, environmental, and allergenic factors resulting in a significant component of inflammation of the airway. Recent directions in therapy differ in taking either the broad-based antagonist or the specific mediator antagonist approach. This review highlights some of the scientific evidence of the operative pathophysiological events and reviews their applicability to the rationale for broad-based combination asthma therapy.
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