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Toxic epidermal necrolysis after celecoxib therapy
Peter Berger1, Daniel Dwyer, Carmela E Corallo
1Department of Dermatology, Box Hill Hospital, Victoria, Australia.
Pharmacotherapy
|September 12, 2002
Summary
Toxic epidermal necrolysis (TEN) is a severe drug reaction causing widespread skin detachment. This case highlights celecoxib as a potential, though rare, cause of TEN.
Area of Science:
- Dermatology
- Pharmacology
- Toxicology
Background:
- Toxic epidermal necrolysis (TEN) is a rare, severe mucocutaneous reaction.
- It is predominantly associated with adverse drug reactions.
- Commonly implicated drugs include sulfonamides, anticonvulsants, allopurinol, and NSAIDs.
Observation:
- A patient developed a generalized desquamating rash.
- The rash appeared after initiating therapy with celecoxib.
- Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID).
Findings:
- This case suggests celecoxib may be implicated in TEN development.
- The patient's presentation was consistent with extensive full-thickness epidermal detachment.
- Further investigation into NSAID-induced TEN is warranted.
Implications:
- Clinicians should consider celecoxib in the differential diagnosis of drug-induced skin reactions resembling TEN.
- Awareness of this potential adverse effect can aid in early diagnosis and management.
- This case expands the list of potential causative agents for TEN.