Related Experiment Video
Updated: Sep 26, 2026

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
Angiotensin-converting enzyme gene polymorphism and coronary heart disease in Turkish type 2 diabetic patients
Mustafa Araz1, Sükrü Aynacioglu, Vahap Okan
1Department of Internal Medicine, Medical Faculty, Gaziantep University, Turkey. araz@gantep.edu.tr
Objective:
It has been suggested that the insertion (I)/deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) may be associated with atherosclerosis. The aim of the study was to examine the association between ACE gene polymorphism and coronary heart disease in Turkish type 2 diabetic patients.
Methods And Results:
A total of 152 (97 female, 55 male) type 2 diabetic patients were included into the study. All patients underwent myocardial perfusion scintigraphic examination and forty-five of them with a perfusion defect underwent coronary angiography.Thirty-eight patients with a coronary stenosis of more than 50% on coronary angiography were considered as having coronary heart disease. The I/D polymorphism was determined by polymerase chain reaction. There was no statistically significant difference in genotypic and allelic frequencies of the ACE I/D polymorphism among patients with and without coronary heart disease (DD:ID:II (%), 32:58:11 and 39:44:17, respectively).
Conclusions:
ACE gene polymorphism is not a significant parameter to determine coronary heart disease in Turkish type 2 diabetic patients.
Related Concept Videos
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Coronary Artery Disease I: Introduction
Coronary Artery Disease II: Pathophysiology
Type II Diabetes I: Introduction
Type II Diabetes II: Pathophysiology

