[Serotonin and 5-hydroxyindolacetate during acute renal ischemia]

During the acute renal ischemia (lasting up to 24 hrs) in rabbits the serotonin level displayed similar changes in the ischemic and contralateral kidney. In the tissues under study serotonin decreased during the first fifteen minutes of ischemia; then a tendency to increase with a maximal rise in the ischemic kidney after a 60-min ischemia was seen; as to the contralateral kidney--the maximal rise occurred after a 3 hr ischemia. At the further stages of ischemia serotonin content fell again, particularly in the ischemic kidney. The blood serotonin level increased somewhat during the 60-min ischemia. An increase in the 5-hydroxyindolacetate concentration in the urine coincided with the period of decrease of the tissue serotonin content.