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Bone marrow-derived endothelial progenitor cells for vascular regeneration
Toshinori Murayama1, Takayuki Asahara
1Division of Cardiovascular Research, St Elizabeth's Medical Center of Boston, Brighton, MA 02135-2997, USA.
Current Opinion in Molecular Therapeutics
|September 12, 2002
Summary
Adult vasculogenesis involves bone marrow (BM)-derived endothelial progenitor cells (EPCs) in neovascularization. These EPCs show therapeutic potential for vascular regeneration and treating vascular diseases.
Area of Science:
- Cardiovascular Biology
- Regenerative Medicine
- Cell Biology
Background:
- Postnatal neovascularization involves both angiogenesis and vasculogenesis.
- Adult vasculogenesis utilizes bone marrow (BM)-derived endothelial progenitor cells (EPCs).
- EPCs are recruited to circulation by cytokines or ischemia for neovascularization.
Purpose of the Study:
- To review the discovery and role of BM-derived EPCs in adult vasculogenesis.
- To explore the therapeutic potential of EPCs for vascular regeneration.
Main Methods:
- Literature review on endothelial progenitor cells and neovascularization.
- Analysis of studies investigating EPC recruitment and incorporation.
- Evaluation of EPC-based therapeutic strategies.
Main Results:
- BM-derived EPCs contribute significantly to adult vasculogenesis.
- EPCs can be mobilized and incorporated into neovascular sites.
- EPCs are a promising therapeutic target for vascular repair.
Conclusions:
- Adult vasculogenesis is a key mechanism in neovascularization, involving BM-derived EPCs.
- EPCs represent a viable 'supply-side' therapeutic approach for vascular regeneration.
- Further research into EPCs could lead to novel treatments for vascular pathologies.