Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recent developments in laboratory automation using magnetic particles for genome analysis.

Kimimichi Obata1, Hideji Tajima, Masafumi Yohda

  • 1Precision System Science Co. Ltd, 88 Kamihongo, Matsudo, Chiba, 271-0064, Japan. kimimichi.obata@pss-europe.de

Pharmacogenomics
|September 12, 2002
PubMed
Summary

Automating genome analysis is advancing, with magnetic particle technology showing promise for nucleic acid purification. This shift enhances biological functional analysis and diagnostic tool development across various research fields.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alternative Extracellular Disulfide Bond Formation by N-terminal Cysteines Supports Functional Expression of Odorant Receptors.

The Journal of biological chemistry·2026
Same author

Amplicon sequence collection of putative polyethylene terephthalate hydrolases from two different composts in Japan.

Microbiology resource announcements·2026
Same author

Trehalulose serves as a distinctive marker for Indonesian stingless bee honey under raw and dehumidified conditions.

Scientific reports·2026
Same author

Structural and functional characterization of sHsp from the marine cyanobacterium <i>Picosynechococcus</i> sp. NKBG15041c.

Biochemistry and biophysics reports·2026
Same author

Complete genome sequence of <i>Azospira</i> sp. strain I13 harboring two distinct nitrous oxide reductase (<i>nosZ</i>) genes.

Microbiology resource announcements·2026
Same author

Efficient production of active recombinant cholesterol oxidase from Rhodococcus erythropolis in Escherichia coli via his-tag assisted refolding strategy for cholesterol oxidation.

Enzyme and microbial technology·2025

Area of Science:

  • Genomics
  • Molecular Biology
  • Biotechnology

Background:

  • Genome analysis research is shifting from sequencing to functional gene analysis.
  • Genome diagnostics show potential for widespread application in human, veterinary, and botanical research.
  • Current genome analysis involves nucleic acid purification, amplification, labeling, and signal detection.

Purpose of the Study:

  • To evaluate technologies for realistic and practical automation in genome analysis.
  • To identify key factors for successful automation, including reagent management and contamination prevention.
  • To highlight magnetic particle methods as a promising approach for automating biological research processes.

Main Methods:

  • Review of existing technologies for each step of genome analysis.

Related Experiment Videos

  • Evaluation of automation suitability for nucleic acid purification, amplification, labeling, and detection.
  • Assessment of magnetic particle-based methods for automation.

    • Main Results:

    • Automation is advanced for most genome analysis steps except nucleic acid purification.
    • Magnetic particle purification methods are accelerating automation development.
    • Magnetic particle technology shows potential for automating various biological research processes, including immunoassays.

    Conclusions:

    • Full automation of genome analysis will become more desirable with the development of diagnostic tools.
    • Selecting suitable technologies is crucial for developing practical automation.
    • Magnetic particle methods offer a promising solution for precise reagent management and risk mitigation in automated genome analysis.