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Published on: July 3, 2025
Fibroblast growth factors in cancer: therapeutic possibilities
Michael Jeffers1, William J LaRochelle, Henri S Lichenstein
1CuraGen Corporation, 322 East Main Street, Branford, Connecticut 06405, USA. mjeffers@curagen.com
Abstract:
The fibroblast growth factor (FGF) family of signalling molecules and its receptors (FGFRs) contribute to normal developmental and physiological processes. However, the subversion of this powerful growth stimulatory pathway has been implicated in the generation of a variety of pathological conditions. This review focuses on the role of FGF/FGFRs in cancer. The case will be made that this signalling pathway is associated with and functionally important for the growth of some human tumours. As such, FGF/FGFRs can be viewed as rational therapeutic oncology targets and strategies used to inhibit these molecules are discussed. The therapeutic exploitation of tumour-associated FGFR expression to deliver toxins or antiproliferative signals to tumour cells is also reviewed, as is the use of FGFs as protein therapeutics to alleviate the side effects of cancer therapy.
Insights
Fibroblast growth factor (FGF) and its receptors (FGFRs) drive cancer growth. Inhibiting FGF/FGFR signaling offers a promising therapeutic strategy for various human tumors.
Area of Science:
- Oncology
- Molecular Biology
- Cell Signaling
Background:
- Fibroblast growth factor (FGF) and its receptors (FGFRs) are crucial for normal development.
- Aberrant FGF/FGFR signaling is implicated in various pathological conditions, including cancer.
Purpose of the Study:
- To review the role of FGF/FGFR signaling in cancer.
- To discuss FGF/FGFRs as therapeutic targets in oncology.
Main Methods:
- Literature review of studies on FGF/FGFR signaling in human tumors.
- Analysis of therapeutic strategies targeting the FGF/FGFR pathway.
Main Results:
- FGF/FGFR signaling is functionally important for the growth of several human tumors.
- Inhibitory strategies targeting FGF/FGFRs are viable therapeutic options.
- Targeting tumor-associated FGFRs can deliver anti-cancer agents.
- FGFs show potential as therapeutics for managing cancer treatment side effects.
Conclusions:
- The FGF/FGFR pathway represents a rational therapeutic target in oncology.
- Targeted inhibition and exploitation of FGF/FGFRs offer promising avenues for cancer treatment and supportive care.
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