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Updated: Sep 29, 2026

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland
Published on: December 1, 2015
IkB kinase alpha: a link in the chain of the mammary cycle
1Department of Pathology, University of Cambridge, UK. rwec2@mole.bio.ac.uk
Abstract:
The transcription factor NF-kappaB exhibits altered activity in some breast cancers but the relevance of this association has not been established. Cao et al.'s elegant study recently published in Cell reveals a NF-kappaB-dependent signalling pathway responsible for epithelial proliferation in the mouse mammary gland. Could this mechanism, rather than prevention of apoptosis, be responsible for the reported association between NF-kappaB and breast cancer? Could the specificity of NF-kappaB modulators of the IkB kinase complex determine the fate of epithelial cells at different stages of mammary development?
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