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Related Experiment Videos

Galectinomics: finding themes in complexity.

Douglas N W Cooper1

  • 1Departments of Psychiatry and Anatomy, University of California, San Francisco, LPPI, Box F-0984, 401 Parnassus Ave., San Francisco, CA 94143-0984, USA. cooper@cgl.ucsf.edu

Biochimica Et Biophysica Acta
|September 12, 2002
PubMed
Summary
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Gene design, expression, crystallization and preliminary diffraction analysis of two isolectins from the fungus Coprinus cinereus: a model for studying functional diversification of galectins in the same organism and their evolutionary pathways.

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Phylogenetic analysis of the vertebrate galectin family.

Molecular biology and evolution·2004
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Genomics research has identified numerous new galectin family members across diverse species, revealing ancient evolutionary origins. This expansion highlights common themes and suggests new research avenues in galectinomics.

Area of Science:

  • Genomics
  • Evolutionary Biology
  • Molecular Biology

Background:

  • Genomic sequence databases have rapidly expanded, driving advancements in genomics.
  • Genomics involves using sequence information to define and compare gene families across species.
  • The galectin gene family is evolutionarily ancient, with members found in vertebrates, invertebrates, and protists.

Purpose of the Study:

  • To review the expansion of the galectin family through galectinomics.
  • To explore the evolutionary history and diversity of galectins.
  • To identify common themes and potential research targets within the galectin family.

Main Methods:

  • Comparative genomics
  • Sequence analysis
  • Bioinformatics approaches to identify and analyze galectin homologs across diverse organisms.

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Main Results:

  • Numerous novel galectin relatives have been identified in a wide range of organisms, including Arabidopsis, Drosophila, Caenorhabditis, Danio, Xenopus, and humans.
  • The galectin family has significantly increased in size and complexity due to these discoveries.
  • Several recurring themes have emerged across the identified galectin members.

Conclusions:

  • The expansion of galectin knowledge through galectinomics provides a more comprehensive understanding of this protein family.
  • The evolutionary ancient nature of galectins is further supported by their presence in diverse taxa.
  • Emerging common themes offer promising directions for future research in galectin function and evolution.