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Related Experiment Videos

The mannose receptor family.

Lucy East1, Clare M Isacke

  • 1The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, Mary-Jean Mitchell Green Building Chester Beatty Laboratories, 237 Fulham Road, SW3 6JB, London, UK. l.east@icr.ac.uk

Biochimica Et Biophysica Acta
|September 12, 2002
PubMed
Summary

The mannose receptor family includes four glycoproteins that recycle between cell membranes and endosomes. These receptors, while structurally similar, bind different ligands and perform distinct cellular functions.

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Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • The mannose receptor (MR) family consists of four type I transmembrane glycoproteins.
  • These receptors possess characteristic structural domains: N-terminal cysteine-rich, fibronectin type II (FNII), and C-type lectin-like domains (CTLDs).
  • Cytoplasmic motifs enable receptor recycling between the plasma membrane and endosomal compartments.

Purpose of the Study:

  • To review the structure and function of the four mannose receptor family members.
  • To highlight the distinct ligand-binding capabilities and functional roles of each receptor.
  • To discuss the evolutionary divergence in domain usage and intracellular trafficking.

Main Methods:

  • Literature review of existing research on mannose receptor family proteins.

Related Experiment Videos

  • Comparative analysis of the structural domains and functional properties of MR, PLA(2)R, DEC-205/gp200-MR6, and Endo180/uPARAP.
  • Examination of endocytic and phagocytic mechanisms mediated by these receptors.

    • Main Results:

    • All four receptors share a common structural framework but exhibit specialized domain interactions.
    • Ligand specificity varies across the family, with different domains mediating distinct molecular interactions.
    • Functional differences include variations in endocytic/phagocytic capabilities and intracellular trafficking pathways.
    • The receptors represent a diverse group of multidomain, multifunctional proteins.

    Conclusions:

    • The mannose receptor family displays remarkable functional diversification despite conserved structural elements.
    • Differential domain usage allows for specialized roles in ligand recognition and cellular processes.
    • Understanding these receptors provides insights into complex cellular signaling and immune responses.