Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Blood into brain after stroke.

David C Hess1, William D Hill, Angeline Martin-Studdard

  • 1Department of Neurology, Medical College of Georgia and VA Medical Center, Augusta, GA 30912, USA. dhess@neuro.mcg.edu

Trends in Molecular Medicine
|September 12, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Conditional Knockout of Indoleamine 2, 3-Dioxygenase-1 in Osteoprogenitor Cells in Mice Results in Sex-dependent Differences in Bone Mass.

Biochimie·2026
Same author

Remote ischaemic conditioning in patients with supratentorial intracerebral haemorrhage (RICH-2): a multicentre, randomised, sham-controlled phase 3 trial in China.

EClinicalMedicine·2026
Same author

Increased Incidence of Methicillin-Resistant Staphylococcus aureus Skin and Soft Tissue Abscesses in Indigenous Children in North Queensland.

Cureus·2026
Same author

MAGEB16 as an epigenetic timing regulator linking X-chromosome biology to neurodevelopmental vulnerability in Autism Spectrum Disorder.

EXCLI journal·2026
Same author

Correction to: Creating Virtual Stroke Networks: Current and Future Role of Artificial Intelligence, Mobile Imaging Applications, and Telehealth in Triage and Treatment of Acute Ischemic Stroke: A Scientific Statement From the American Heart Association.

Stroke·2026
Same author

Neuroinflammatory and functional outcomes after TBI are sex-dependent: Lessons from estrous-phase stratified female mice.

Neurochemistry international·2026
Same journal

Hyocholic acids: Third bile acids for neonatal health.

Trends in molecular medicine·2026
Same journal

Clonal hematopoiesis in Alzheimer's brain: Protective, pathogenic, and context-dependent?

Trends in molecular medicine·2026
Same journal

Targeting amino acid metabolism in hepatocellular carcinoma.

Trends in molecular medicine·2026
Same journal

Turning perfusion into repair through ferroptosis blockade.

Trends in molecular medicine·2026
Same journal

CaMKK2: A tumor stress-integration node.

Trends in molecular medicine·2026
Same journal

Precision gene editing: From proof-of-concept to curative therapies.

Trends in molecular medicine·2026
See all related articles

Bone marrow cells can transform into brain cells after a stroke. This study shows bone marrow-derived cells become cerebral endothelial and NeuN-expressing cells following cerebral infarction in mice.

Area of Science:

  • Neuroscience
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Cerebral infarction, or stroke, leads to significant brain damage.
  • The brain's limited capacity for self-repair poses a challenge for recovery.
  • Investigating the potential of bone marrow-derived cells in brain repair is crucial.

Purpose of the Study:

  • To determine if bone marrow-derived cells can contribute to brain repair after cerebral infarction.
  • To identify the specific cell types bone marrow cells differentiate into within the brain post-stroke.

Main Methods:

  • A bone-marrow transplantation chimera model was established in mice.
  • Cerebral infarction was induced in the chimeric mice.
  • Cellular differentiation and lineage tracing were analyzed post-infarction.

Related Experiment Videos

Main Results:

  • Bone marrow-derived cells were observed to migrate to the site of cerebral infarction.
  • These cells were found to differentiate into cerebral endothelial cells, contributing to blood vessel repair.
  • Additionally, bone marrow-derived cells differentiated into NeuN-expressing cells, which are neuronal markers.

Conclusions:

  • Bone marrow-derived cells possess the potential to differentiate into crucial brain cell types after stroke.
  • This finding suggests a possible therapeutic avenue for stroke recovery using bone marrow stem cells.
  • Further research can explore harnessing this differentiation capacity for clinical applications in stroke treatment.