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Related Experiment Videos

Proton chemical shift imaging in pick complex.

Osamu Kizu1, Kei Yamada, Tsunehiko Nishimura

  • 1Department of Radiology, Kyoto Prefectural University of Medicine, Japan.

AJNR. American Journal of Neuroradiology
|September 12, 2002
PubMed
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Proton chemical shift imaging ((1)H-CSI) revealed reduced N-acetylaspartate (NAA) in patients with Pick complex (PC). This neuroimaging technique may help understand the right-hemisphere-dominant neurodegeneration in PC.

Area of Science:

  • Neuroimaging
  • Metabolic Brain Imaging
  • Neurodegenerative Diseases

Background:

  • Pick complex (PC) encompasses diseases with overlapping pathology and clinical features, complicating in vivo neuropathologic observation.
  • Accurate in vivo assessment of neuropathologic changes is crucial for classifying PC subtypes.

Purpose of the Study:

  • To evaluate brain metabolic changes in patients with Pick complex using proton chemical shift imaging ((1)H-CSI).

Main Methods:

  • Nine patients with PC (including frontotemporal dementia, corticobasal degeneration, and primary progressive aphasia) and five healthy controls underwent (1)H-CSI.
  • Volumes of interest in the basal ganglia and perisylvian regions were analyzed for N-acetylaspartate (NAA), creatine (Cr), and choline (Cho) metabolite ratios.

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Main Results:

  • Patients with PC showed reduced NAA/choline (Cho) ratios in the right basal ganglia.
  • In corticobasal degeneration and primary progressive aphasia subtypes, decreased NAA/creatine (Cr) values were observed in the right perisylvian region.

Conclusions:

  • (1)H-CSI indicated widespread reduction in NAA levels in PC, suggesting neurodegeneration.
  • Reduced NAA in the right hemisphere may signify dominant right-sided pathology in some PC cases.
  • (1)H-CSI offers unique insights into PC's pathologic processes, surpassing other imaging modalities.