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Related Experiment Videos

Delta FosB regulates wheel running.

Martin Werme1, Chad Messer, Lars Olson

  • 1Department of Neuroscience, Karolinska Institutet, Stockholm, S-171 77 Sweden.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|September 12, 2002
PubMed
Summary

Voluntary wheel running increases DeltaFosB levels in the brain, similar to drugs of abuse. Overexpressing DeltaFosB in specific neurons influences running behavior, suggesting its role in natural and drug reward pathways.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Behavioral Science

Background:

  • DeltaFosB is a transcription factor known to accumulate in the brain following chronic stimuli, such as drug abuse.
  • Its accumulation is region-specific, particularly in the striatum, a key area for reward processing.

Purpose of the Study:

  • To investigate the effect of voluntary wheel running, a natural rewarding behavior, on DeltaFosB levels in striatal regions.
  • To explore the role of DeltaFosB in controlling running behavior through overexpression studies in specific neuronal populations.

Main Methods:

  • Lewis rats were given access to running wheels for 30 days to measure DeltaFosB levels in the nucleus accumbens.
  • Mice with inducible overexpression of DeltaFosB in dynorphin- or enkephalin-containing striatal neurons were used to assess running behavior.

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Main Results:

  • Voluntary wheel running significantly increased DeltaFosB levels in the nucleus accumbens compared to controls.
  • Overexpression of DeltaFosB in dynorphin neurons enhanced running behavior, while overexpression in enkephalin neurons reduced it.

Conclusions:

  • Voluntary running, like drugs of abuse, elevates DeltaFosB in brain reward pathways.
  • DeltaFosB plays a crucial role in modulating both natural and drug-induced reward behaviors, particularly through its effects on distinct striatal neuronal populations.