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Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
Published on: October 7, 2011
Strategies for the identification and analysis of viral immune-evasive genes--cytomegalovirus as an example
A Gutermann1, A Bubeck, M Wagner
1Max-von-Pettenkofer Institut, Ludwig-Maximilians-Universität München, 80336 München, Germany.
Abstract:
Co-evolution of herpesviruses with their hosts has resulted in multiple interactions between viral genes and cellular functions. Some interactions control genomic maintenance and replication in specific tissues, other affect the immune control at various stages. Few immunomodulatory functions of genes can be predicted by sequence homology. The majority of genes with immunomodulatory properties only become apparent in functional assays. This chapter reviews procedures which have been used for successful identification of immunomodulatory genes in the past and deals with recent methods which may be applicable for the identification of additional immunomodulatory functions unknown so far.
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