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Published on: February 28, 2019
Function of CMV-encoded MHC class I homologues
H E Farrell1, N J Davis-Poynter, D M Andrews
1Animal Health Trust, Virology Section, Kentford, Newmarket, Suffolk CB8 7UU, UK.
Current Topics in Microbiology and Immunology
|September 13, 2002
Summary
Cytomegaloviruses (CMVs) possess MHC class I homologues that may disrupt host antiviral immunity. This review explores their molecular and cellular roles in the CMV life cycle.
Area of Science:
- Virology
- Immunology
- Molecular Biology
Background:
- Major histocompatibility complex (MHC) class I proteins are crucial for cellular immunity.
- Homologues of MHC class I have been identified in human, murine, and rat cytomegaloviruses (CMVs).
Purpose of the Study:
- To review recent studies on CMV MHC class I homologues.
- To present current hypotheses regarding their function in the CMV life cycle.
Main Methods:
- Review of molecular, cellular, and whole-animal studies.
- Analysis of genomic data for CMV MHC class I homologues.
Main Results:
- CMV MHC class I homologues are present across different species.
- These viral proteins are hypothesized to interfere with host antiviral responses.
Conclusions:
- CMV MHC class I homologues likely play a significant role in subverting host immunity.
- Understanding these viral proteins is key to comprehending the CMV life cycle and pathogenesis.
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