Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selenium-based pharmacological agents: an update.

Sheldon W May1

  • 1School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.

Expert Opinion on Investigational Drugs
|September 13, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Amidation inhibitors 4-phenyl-3-butenoic acid and 5-(acetylamino)-4-oxo-6-phenyl-2-hexenoic acid methyl ester are novel HDAC inhibitors with anti-tumorigenic properties.

Investigational new drugs·2015
Same author

Conifer somatic embryogenesis: improvements by supplementation of medium with oxidation-reduction agents.

Tree physiology·2015
Same author

Pharmacokinetics, antitumor and cardioprotective effects of liposome-encapsulated phenylaminoethyl selenide in human prostate cancer rodent models.

Pharmaceutical research·2014
Same author

Inhibition of JNK and p38 MAPK phosphorylation by 5-(acetylamino)-4-oxo-6-phenyl-2-hexenoic acid methyl ester and 4-phenyl-butenoic acid decreases substance P-induced TNF-α upregulation in macrophages.

International immunopharmacology·2014
Same author

Cellular antioxidant activity of phenylaminoethyl selenides as monitored by chemiluminescence of peroxalate nanoparticles and by reduction of lipopolysaccharide-induced oxidative stress.

Enzyme and microbial technology·2013
Same author

Myo-inositol hexakisphosphate, isolated from female gametophyte tissue of loblolly pine, inhibits growth of early-stage somatic embryos.

The New phytologist·2011
Same journal

Advancements in longevity pharmacology research - are we finally seeing clinical progression?

Expert opinion on investigational drugs·2026
Same journal

Consideration of the use of nalbuphine in idiopathic pulmonary fibrosis-associated cough: to cough or not to cough so much?

Expert opinion on investigational drugs·2026
Same journal

Investigational new drug TAP-1502 beginning clinical study for seborrheic dermatitis.

Expert opinion on investigational drugs·2026
Same journal

Cannabinoid use in adults with sickle cell disease: therapeutic development and clinical insights.

Expert opinion on investigational drugs·2026
Same journal

Odronextamab: a bispecific antibody for follicular lymphoma.

Expert opinion on investigational drugs·2026
Same journal

Evaluating the investigational drug landscape for <i>ESR1</i>-mutated, estrogen receptor-positive, HER2-negative metastatic breast cancer.

Expert opinion on investigational drugs·2026
See all related articles

Selenium is vital for antioxidant enzymes and preventing diseases like cancer. New selenium-based drugs are being developed to target various health conditions, offering therapeutic potential.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Public Health

Background:

  • Selenium is an essential dietary antioxidant and a component of critical enzymes like glutathione peroxidase and thioredoxin reductase.
  • Low plasma selenium levels are linked to increased risk for cancer, cardiovascular disease, osteoarthritis, and AIDS.
  • Emerging evidence suggests selenium's anti-cancer effects involve specific metabolites, not solely enzyme expression.

Purpose of the Study:

  • To explore the current interest in selenium's biochemistry and pharmacology for public health.
  • To review the role of selenium in cellular protection against oxidative damage.
  • To highlight the development of novel selenium-based pharmaceutical agents.

Main Methods:

  • Literature review on selenium's role in enzyme function and disease risk.

Related Experiment Videos

  • Analysis of ongoing human trials for selenium supplementation.
  • Examination of emerging pharmaceutical agents targeting selenium metabolism.

    • Main Results:

    • Selenium is crucial for enzymes protecting against oxidative stress.
    • Low selenium is a risk factor for major diseases, with ongoing supplementation trials.
    • Novel selenium-based drugs are in development for hypertension, cancer, viral infections, and more.

    Conclusions:

    • Selenium's significance extends beyond antioxidant roles to essential enzyme functions.
    • Pharmaceutical development is leveraging selenium's properties for diverse therapeutic applications.
    • Increased understanding of selenium biology will drive future drug discovery for various diseases.