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Antithrombin III activity and platelet count are more likely to decrease in twin pregnancies than in singleton

Tetsuo Tsunoda¹, Akihide Ohkuchi, Akio Izumi

¹Deparetment of Obstetrics and Gynecology, Jichi Medical School, Tochigi, Japan.

Acta Obstetricia Et Gynecologica Scandinavica

|September 13, 2002

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Women with twin pregnancies experience greater decreases in antithrombin III activity and platelet counts compared to those with singleton pregnancies. This suggests increased thrombin generation in twin gestations.

Area of Science:

Obstetrics and Gynecology
Hematology
Perinatology

Background:

The comparative changes in antithrombin III activity and platelet count between twin and singleton pregnancies are not well-established.
Investigating these hematological parameters is crucial for understanding pregnancy complications.

Purpose of the Study:

To compare the changes in antithrombin III activity and platelet count in women with twin versus singleton pregnancies.
To explore the relationship between these changes and markers of coagulation activation.

Main Methods:

A cohort study involving 56 women with twin pregnancies and 692 with singleton pregnancies.
Antithrombin III activity and platelet counts were measured at two time points during gestation (26-31 weeks and 32-40 weeks).
Thrombin-antithrombin and plasmin-alpha2 plasmin inhibitor complexes were also assessed.

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Main Results:

Twin pregnancies showed significantly greater decreases in antithrombin III activity and platelet counts over gestation compared to singleton pregnancies.
Serum thrombin-antithrombin complex levels were significantly higher in twin pregnancies.
Increased thrombin-antithrombin complex levels correlated with decreased antithrombin III activity in twin pregnancies.

Conclusions:

Antithrombin III activity and platelet counts decrease more significantly in twin pregnancies than in singleton pregnancies.
Elevated thrombin generation is a likely contributor to these observed hematological changes in twin gestations.