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Published on: July 17, 2014
Immunity to asexual blood stage malaria and vaccine approaches
Jiraprapa Wipasa1, Salenna Elliott, Huji Xu
1The Cooperative Research Centre for Vaccine Technology, The Queensland Institute of Medical Research, Australia.
Abstract:
The development of a malaria vaccine seems to be a definite possibility despite the fact that even individuals with a life time of endemic exposure do not develop sterile immunity. An effective malaria vaccine would be invaluable in preventing malaria-associated deaths in endemic areas, especially amongst children less than 5 years of age and pregnant women. This review discusses our current understanding of immunity against the asexual blood stage of malaria - the stage that is responsible for the symptoms of the disease - and approaches to the design of an asexual blood stage vaccine.
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