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Related Experiment Videos

Intermediate filaments: vimentin moves in.

Emma J Clarke1, Viki Allan

  • 1CNR Institute of Neuroscience, Cellular and Molecular Pharmacology, Via Vanvitelli 32, 20129 Milan, Italy.

Current Biology : CB
|September 13, 2002
PubMed
Summary
This summary is machine-generated.

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Vimentin intermediate filaments move along cellular microtubules. Cytoplasmic dynein has been identified as the motor protein responsible for the inward movement of these filaments.

Area of Science:

  • Cell Biology
  • Cytoskeletal Dynamics
  • Molecular Motors

Background:

  • Vimentin intermediate filaments (VIFs) are crucial for cell structure and function.
  • VIFs exhibit bi-directional movement along cellular microtubules.
  • The motor driving the inward movement of VIFs remained unidentified.

Purpose of the Study:

  • To identify the molecular motor responsible for the inward transport of vimentin intermediate filaments along microtubules.

Main Methods:

  • Utilized advanced live-cell imaging techniques.
  • Investigated the role of microtubule-associated motor proteins.

Main Results:

  • Identified cytoplasmic dynein as the motor protein mediating inward VIF movement.

Related Experiment Videos

  • Demonstrated dynein's direct involvement in the bi-directional transport of VIFs.

    • Conclusions:

    • Cytoplasmic dynein is the key motor for inward vimentin transport.
    • This finding clarifies the mechanism of VIF dynamics within the cell.