Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selective serotonin reuptake inhibitors decrease impulsive behavior as measured by an adjusting delay procedure in

Mary C Wolff1, J David Leander

  • 1Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA. wolff_mary_c@lilly.com

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|September 13, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Behavioral Effects of a Novel Benzofuranyl-Piperazine Serotonin-2C Receptor Agonist Suggest a Potential Therapeutic Application in the Treatment of Obsessive-Compulsive Disorder.

Frontiers in psychiatry·2017
Same author

GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists.

Expert opinion on investigational drugs·2013
Same author

GLYX-13, a NMDA receptor glycine-site functional partial agonist, induces antidepressant-like effects without ketamine-like side effects.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2013
Same author

Acute exposure to a novel object during consolidation enhances cognition.

Neuroreport·2004
Same author

SR141716A, a cannabinoid CB1 receptor antagonist, improves memory in a delayed radial maze task.

European journal of pharmacology·2003
Same author

Comparison of the effects of antipsychotics on a delayed radial maze task in the rat.

Psychopharmacology·2003
Same journal

Cultural humility in the teaching and practice of clinical care.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same journal

Kappa opioid receptors mediate aversion-and it matters.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same journal

Splice isoforms of the histone variant macroH2A1 differentially regulate hippocampal gene expression and memory formation.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same journal

Chronic ethanol self-administration alters dopamine in the caudate nucleus and putamen of rhesus macaques in a sex-dependent manner.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same journal

In memoriam-Shigeto Yamawaki, M.D., Ph.D. (1954-2026).

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same journal

Top-down control of sustained attention by medial prefrontal cortex-locus coeruleus (mPFC-LC) projection neurons during the rodent continuous performance test (rCPT).

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
See all related articles

Selective serotonin reuptake inhibitors (SSRIs) show promise in reducing impulsive behavior by increasing delayed gratification. Combining SSRIs with a 5-HT(1A) agonist may accelerate these therapeutic effects.

Area of Science:

  • Behavioral pharmacology
  • Neuroscience
  • Animal models of impulsivity

Background:

  • Impulsive behavior, characterized by an inability to delay gratification, is a significant concern.
  • Understanding the neurobiological underpinnings of impulsivity is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the effects of various pharmacological agents on the delay of gratification in pigeons.
  • To explore the potential of selective serotonin reuptake inhibitors (SSRIs) and their interaction with 5-HT(1A) receptor modulators in modulating impulsive behavior.

Main Methods:

  • Development of an adjustable delay schedule to measure indifference points for delayed reinforcement in pigeons.
  • Acute and chronic administration of alprazolam, chlordiazepoxide, 8-OH-DPAT (5-HT(1A) agonist), WAY100635 (5-HT(1A) antagonist), and SSRIs (fluoxetine, citalopram, paroxetine).

Related Experiment Videos

Main Results:

  • Acute anxiolytics (alprazolam, chlordiazepoxide) decreased tolerated delay periods.
  • Chronic SSRI administration (fluoxetine, citalopram, paroxetine) significantly increased delay periods, indicating reduced impulsivity.
  • Co-administration of fluoxetine with a 5-HT(1A) agonist, but not an antagonist, accelerated the increase in delay tolerance.

Conclusions:

  • Chronic SSRI treatment effectively reduces impulsive behavior in this animal model.
  • The addition of a 5-HT(1A) agonist may enhance and hasten the therapeutic effects of SSRIs in treating impulsivity.