Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inbred strain variation in lung function.

Claudia Reinhard1, Gunter Eder, Helmut Fuchs

  • 1Institute for Inhalation Biology, GSF-National Research Center for Environment and Health, D-85758 Neuherberg/Munich, Germany. reinhard@gsf.de

Mammalian Genome : Official Journal of the International Mammalian Genome Society
|September 13, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Standardized Pipeline for Metabolism and Cognition in GO-DS21 Mouse Model: Investigating Down Syndrome Comorbidities.

Current protocols·2026
Same author

SEARCHING FOR NEW GENES THAT CAUSE USHER SYNDROME.

American journal of ophthalmology·2026
Same author

Aminoadipate-semialdehyde synthase, a potential target for substrate reduction therapy in glutaric aciduria type 1.

Scientific reports·2026
Same author

Rethinking ratio-based normalization towards model-based approaches in heart weight analysis.

Scientific reports·2026
Same author

Correction: Establishing standardized transthoracic echocardiography reference ranges for mouse models: insights into the impact of anesthesia, sex, and age.

Frontiers in cardiovascular medicine·2026
Same author

Establishing standardized transthoracic echocardiography reference ranges for mouse models: insights into the impact of anesthesia, sex, and age.

Frontiers in cardiovascular medicine·2026
Same journal

Neuroinflammation in glaucoma: a myriad of cellular pathways and players.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

Correction: THBS1: a biomarker for PCOS and its role in pathogenesis via the PI3K/AKT signaling pathway.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

Elucidating the therapeutic targets and multi-target mechanisms of salvianolic acid A for diabetic nephropathy.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

DeepDisSNP: Predicting disease-associated SNPs by representation learning on disease and SNP linkage disequilibrium networks.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

A comprehensive full-length transcriptome atlas across multiple organs of an Indian yak breed-Arunachali.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

Detection of a complex chromosomal rearrangement in a novel mouse mutant by optical genome mapping.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
See all related articles

Mouse strain differences significantly impact lung function parameters, with considerable variation observed in lung volumes and mechanics. These findings highlight heritable genetic traits influencing pulmonary function, essential for future genetic studies.

Area of Science:

  • Pulmonary Physiology
  • Comparative Genomics
  • Mouse Models

Background:

  • Understanding strain-specific variations in lung function is crucial for interpreting physiological studies in mice.
  • The Mouse Phenome Project provides a framework for characterizing mouse strain phenotypes.

Purpose of the Study:

  • To quantify strain-specific phenotype variance in lung function parameters across common inbred laboratory mouse strains.
  • To assess sex differences in lung function within these strains.
  • To establish a foundation for genetic studies on pulmonary function.

Main Methods:

  • Lung volumes, mechanics, and diffusing capacity were measured in male and female mice from seven common inbred strains.
  • Standardized respiratory maneuvers were performed using a computer-controlled servo-ventilator in anesthetized animals.

Related Experiment Videos

  • Data were analyzed to identify strain and sex-specific differences.

    • Main Results:

    • Significant diversity was observed between strains for all lung function parameters, with total lung capacity varying by 50% and static lung compliance by nearly twofold.
    • Sex differences were noted in 83% of absolute lung function parameters, typically normalized by body or lung size.
    • Variability in dead space volume and respiratory system resistance was minimal but statistically significant.
    • No clear allometric relationships or consistent reflection of genealogical relationships in pulmonary function phenotypes were found.

    Conclusions:

    • Substantial heritable genetic variation exists for pulmonary function in laboratory mice.
    • These strain-specific lung function data are foundational for subsequent genetic research into respiratory diseases.
    • Mouse models offer valuable insights into the genetic basis of lung physiology.