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A diffusion-ordered NMR spectroscopy study of the solubilization of artemisinin by octanoyl-6-O-ascorbic acid
Anna Rita Bilia1, M Camilla Bergonzi, Francesco F Vincieri
1Department of Pharmaceutical Sciences, University of Florence, via Gino Capponi 9, 50121 Firenze, Italy.
Abstract:
Artemisinin (QHS) is a natural drug with a very low solubility in water. To improve its availability in hydrophilic media, it was solubilized in micellar dispersions of octanoyl-6-O-ascorbic acid (ASC8), a relatively novel surfactant that combines surface activity with powerful performance as radical scavenger. In this article we report a study based on diffusion-ordered NMR spectroscopy (DOSY) measurements carried out on QHS/ASC8 micellar dispersions. QHS is efficiently solubilized by ASC8 micelles, with no significant perturbation of the micellisation.
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