[Characteristics of pharmacodynamics of drugs after excimer laser surgery (an experimental study)]

Pharmacodynamics of dexamethasone, fluoromethanol, sodium diclofenak, and tobramicin after photorefraction keratectomy (PRK) and intrastromal laser keratectomy (ILK) was studied in rabbits. Eximer laser operations modulated the barrier functions of the cornea. The highest concentrations of drugs in anterior chamber humor during the first 20 min after instillations was observed after ILK in comparison with the control (intact cornea). The highest coefficient of effective drug diffusion through the cornea was observed after PRK in comparison with ILK. The drug efficiency was higher after ILK than after PRK, which is seen from the maximum concentrations of drugs entering the cornea immediately after instillation and prolongation of the drug effect due to its decelerated diffusion through the cornea.