What is evidence-based medicine?
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Updated: Aug 14, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Victor M Montori1, Gordon H Guyatt
1Division of Endocrinology, Metabolism, Nutrition, and Internal Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
Abstract:
Evidence-based practice requires clinical expertise, common sense, understanding of the circumstances and values of the patient, and judicious application of the best available evidence. This article discusses evidence-based medicine as an explicit and formal problem-solving strategy.
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