Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Androgen dependent brain differentiation and life span.

G Dörner, G Hinz

    Endokrinologie
    |August 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Congenital Pulmonary Stenosis, with Special Consideration of the Nature of the Secondary Blood Changes.

    Proceedings of the Royal Society of Medicine·2009
    Same author

    Congenital Obliteration (or Congenital Atresia) of Bile-ducts, with Hepatic Cirrhosis.

    Proceedings of the Royal Society of Medicine·2009
    Same author

    Persistent Œdema of Right Hand and Forearm after Slight Tramautism.

    Proceedings of the Royal Society of Medicine·2009
    Same author

    Diffusion of Cs atoms in Ne buffer gas measured by optical magnetic resonance tomography.

    Optics express·2009
    Same author

    Brefeldin A action and recovery in Chlamydomonas are rapid and involve fusion and fission of Golgi cisternae.

    Plant biology (Stuttgart, Germany)·2007
    Same author

    Choroidal blood flow and arterial blood pressure.

    Eye (London, England)·2003
    Same journal

    Cytophysiological response of the pineal gland to long-term administration of norethisterone (a progestogen-only contraceptive) in rats.

    Endokrinologie·1982
    Same journal

    Action of sex-hormones on thyroid gland function of the domestic duckling.

    Endokrinologie·1982
    Same journal

    The nature of inhibition of thyroid monoamine oxidase by thyroxine in rat thyroid.

    Endokrinologie·1982
    Same journal

    A possible role for human growth hormone (HGH) in the protection from glucose-induced hyperkalemia in normaldosteronemic diabetes.

    Endokrinologie·1982
    Same journal

    Annual testicular cycles and correlatory histochemical changes exhibited by the nucleus lateralis tuberis (NLT) in the Indian catfish, Clarias batrachus (linn.).

    Endokrinologie·1982
    Same journal

    Changes of triiodothyronine and thyroxine in patients with thyrocardiac disease and their relationship to systolic time intervals.

    Endokrinologie·1982
    See all related articles

    Neonatal hormone exposure significantly influences brain development in rats. Testosterone exposure in female rats and its absence in male rats during early life alters brain differentiation, impacting sexual development and behavior.

    Area of Science:

    • Neuroendocrinology
    • Developmental neuroscience
    • Behavioral endocrinology

    Background:

    • Neonatal hormone exposure is critical for sexual differentiation of the brain.
    • Understanding these organizational effects is key to comprehending sex-based behavioral differences.

    Purpose of the Study:

    • To investigate the effects of neonatal androgen exposure on brain differentiation in female rats.
    • To examine the impact of early androgen deprivation on brain differentiation in male rats.
    • To establish animal models with specific brain differentiation patterns for further study.

    Main Methods:

    • Female rats received subcutaneous testosterone propionate on postnatal day 1.
    • Male rats were orchidectomized on postnatal day 1 or day 75.

    Related Experiment Videos

  • Control groups included intact females and late-orchidectomized males.
  • All animals were of the Sprague-Dawley-derived strain and housed under standard conditions.

    • Main Results:

    • Neonatal testosterone administration induced male-type brain differentiation in genetic female rats.
    • Early orchidectomy in males resulted in female-type brain differentiation.
    • These manipulations created distinct groups with altered sexual brain development.

    Conclusions:

    • Neonatal hormonal milieu plays a crucial role in organizing the brain's sexual characteristics.
    • Experimental manipulation of early androgen exposure can reversibly alter brain sexual differentiation.
    • These findings contribute to understanding the neurobiological basis of sex differences.