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Bisbinaphthyl macrocycle-based highly enantioselective fluorescent sensors for alpha-hydroxycarboxylic acids
Jing Lin1, Hui-Chang Zhang, Lin Pu
1Department of Chemistry, University of Virginia, Charlottesville 22904-4319, USA.
Organic Letters
|September 14, 2002
Abstract:
[structure: see text] Bisbinaphthyl-based macrocycles are found to carry out highly enantioselective fluorescent recognition of alpha-hydroxycarboxylic acids. It is observed that within a certain concentration range, one enantiomer of the chiral acids can increase the fluorescence intensity of the macrocycles by 2-3-fold, while the other enantiomer scarcely enhances the fluorescence. Such unusually high enantioselective responses make these macrocycles very attractive as fluorescent sensors in determining the enantiomeric composition of alpha-hydroxycarboxylic acids.