Unusual sulfamate indoles and a novel indolo[3,2-a]carbazole from Ancorina sp
Karina M Meragelman1, Lyndon M West, Peter T Northcote
1Molecular Targets Drug Discovery Program, Center for Cancer Research, NCI-Frederick, Frederick, Maryland 21702-1201, USA.
Abstract:
Four new indoles, ancorinolates A-C and bis-ancorinolate B, which contain sulfamate and sulfate groups, were isolated from the aqueous extract of the sponge Ancorina sp. In addition, ancorinazole, an indolo[3,2-a]carbazole also possessing sulfamate and sulfate groups, was isolated from two separate New Zealand collections of Ancorina sp. Ancorinazole is the first indolo[3,2-a]carbazole described as a natural product. Ancorinolates A (1) and C (3) showed weak HIV-inhibitory activity in the XTT-based, anticytopathicity assay.
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