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Synthesis and structure of a stabilized 10-membered cyclic enediyne
Wolfgang Pitsch1, Michael Klein, Manfred Zabel
1Institut für Organische Chemie, Universität Regensburg, D-93040 Regensburg, Germany.
The Journal of Organic Chemistry
|September 14, 2002
Abstract:
The synthesis and structure of an acetal protected 10-membered cyclic enediyne-1,2-diol rac-10 is reported. The conformational constrain of the unsaturated macrocycle by the acetal protection group prevents the thermal cyclization reaction of the endiyne during synthesis and purification.