Radiation enteritis
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Updated: Sep 29, 2026

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
Published on: July 27, 2022
Mike M Bismar1, Frank A Sinicrope
1Department of Gastrointestinal Medicine and Nutrition, M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 436, Houston, TX 77030, USA.
Abstract:
The frequent use of radiotherapy for abdominal and pelvic malignancies results in an increased risk of radiation enteritis. An increased understanding of the tissue response and the clinical features of radiation enteritis has led to advances in the prevention and management of this condition. Importantly, improvements in the delivery of radiotherapy, including techniques to reduce the amount of exposed small intestine in the radiation field, represent a critical strategy for prevention. Data indicate that radioprotectant agents have the potential to reduce intestinal mucosal injury and may be beneficial in reducing both acute and chronic side effects of radiotherapy.
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