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Macrophage-enhanced germination of Bacillus anthracis endospores requires gerS
John A W Ireland1, Philip C Hanna
1Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Infection and Immunity
|September 14, 2002
Abstract:
Germination of Bacillus anthracis Sterne and plasmidless Delta-Sterne endospores was dramatically enhanced in RAW264.7 macrophage-like cells, while germination of nonpathogenic Bacillus endospores was not. Elimination of gerS, a germinant receptor locus, caused a complete loss of cell-enhanced germination, implicating gerS in the breaking of endospore dormancy in vivo.