Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Human lymphocyte chromosome changes induced by x-rays].

Monika Bellorín-Fernández1, Janice Fernández-D'Pool

  • 1Instituto de Medicina del Trabajo e Higiene Industrial, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.

Investigacion Clinica
|September 17, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Musculoskeletal pain in Venezuelan oil tanker crews].

Investigacion clinica·2014
Same author

[Musculoeskeletal symptoms in bus drivers of a university institution].

Investigacion clinica·2012
Same author

[Seminal profile in workers exposed to cholinesterase inhibitor insecticides].

Investigacion clinica·2003
Same author

[Hand injuries in workers on the eastern shore of Marcaibo Lake in the state of Zulia, Venezuela, 1986-1993].

Investigacion clinica·2002

X-ray exposure causes dose-dependent increases in chromosomal alterations in human lymphocytes. Cytogenetic analysis effectively monitors radiation dose and biological effects.

Area of Science:

  • Radiation biology
  • Human genetics
  • Cytogenetics

Context:

  • X-rays are a common source of ionizing radiation.
  • Understanding radiation-induced biological effects is crucial for health and safety.
  • Human lymphocytes are sensitive indicators of radiation damage.

Purpose:

  • To determine and characterize chromosomal alterations in human lymphocytes induced by x-rays.
  • To establish a dose-response relationship between x-ray exposure and chromosomal damage.
  • To evaluate the utility of cytogenetic analysis for biological dosimetry.

Summary:

  • Human lymphocytes were exposed to varying doses of x-rays (0.5-4 Gy).
  • Chromosomal analysis using G banding revealed a linear increase in abnormal metaphases and structural alterations (translocations, fragile sites, deletions) with increasing radiation dose.

Related Experiment Videos

  • Chromosome 1 was most frequently affected, followed by chromosomes 3, 10, 6, 7, and 9.

    • Impact:

    • The study confirms a linear relationship between x-ray dose and chromosomal damage in lymphocytes.
    • Cytogenetic analysis serves as a valuable tool for assessing absorbed radiation dose and biological effects in humans.
    • Findings contribute to radiation protection and risk assessment protocols.