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Polymorphism of esterase D in some population groups in Japan
Human Heredity
|January 1, 1975
Summary
Esterase D (Es D) genetic variations were studied in over 1,000 blood samples. High Es D2 allele frequencies were found in Japanese populations, suggesting its utility in genetic and forensic studies.
Area of Science:
- Biochemistry
- Genetics
- Anthropology
Background:
- Esterase D (Es D) is an enzyme found in red blood cells.
- Understanding the genetic variations of Es D is important for population genetics and forensic science.
Purpose of the Study:
- To determine the electrophoretic types and allele frequencies of red cell esterase D (Es D) in Japanese populations.
- To compare these frequencies with other ethnic groups worldwide.
Main Methods:
- Electrophoretic analysis of red blood cell esterase D (Es D) phenotypes.
- Calculation of allele frequencies from phenotype data in over 1,000 blood samples from Tokyo, Ainu of Hokkaido, and Ryukyuans of Okinawa.
Main Results:
- The allele frequency for Es D2 in Tokyo samples was 0.342.
- Es D2 frequencies were 0.273 in Ainu and 0.369 in Ryukyuans.
- These frequencies are significantly higher than those reported for Europeans, Negroes, and Asiatic Indians.
Conclusions:
- Esterase D exhibits significant genetic heterogeneity in East Asian populations.
- Es D serves as a valuable genetic marker for anthropological and forensic applications in Mongoloid groups.