Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

PROSITE: a documented database using patterns and profiles as motif descriptors.

Christian J A Sigrist1, Lorenzo Cerutti, Nicolas Hulo

  • 1Swiss Institute of Bioinformatics CMU, University of Geneva. christian.sigrist@isb-sib.ch

Briefings in Bioinformatics
|September 17, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Potato foliar infection with Phytophthora infestans drives strong, cultivar-specific shifts in rhizosphere communities.

Environmental microbiome·2026
Same author

Swiss community-based surveillance of respiratory virus co-occurrence in 2022-2024.

Microbiology spectrum·2026
Same author

The association between the composition of the early-life intestinal microbiome and eczema in the first year of life.

Frontiers in microbiomes·2026
Same author

2Pipe starts with a question: matching you with the correct pipeline for MAG reconstruction.

mSystems·2026
Same author

A Spinster-like Transporter at the Inner Membrane Complex is critical for Toxoplasma gondii cytokinesis, motility and invasion.

PLoS pathogens·2026
Same author

An innovative approach for anti-respiratory syncytial virus compound discovery from plant extracts, combining high-throughput screening and metabolomics.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026

PROSITE is a foundational protein database for identifying protein families and domains using patterns and profiles. Its ongoing evolution and integration with SWISS-PROT enhance protein annotation accuracy and database utility.

Area of Science:

  • Bioinformatics
  • Molecular Biology
  • Computational Biology

Background:

  • PROSITE is a pioneering database for protein family and domain identification.
  • It contains a comprehensive collection of biologically significant motifs, including patterns and profiles.
  • PROSITE has a long history of continuous development and refinement.

Purpose of the Study:

  • To review the main characteristics of the PROSITE database.
  • To describe the techniques used for protein family and domain identification within PROSITE.
  • To highlight the symbiotic relationship between PROSITE and the SWISS-PROT database.

Main Methods:

  • Review of PROSITE database content and features.
  • Analysis of motif-based protein identification techniques (patterns and profiles).

Related Experiment Videos

  • Examination of the integration and data exchange with the SWISS-PROT protein database.

    • Main Results:

    • PROSITE offers a robust collection of motifs for detecting protein families and domains.
    • The database employs patterns and profiles for sensitive and specific identification.
    • PROSITE's linkage with SWISS-PROT facilitates motif evaluation and annotation.

    Conclusions:

    • PROSITE remains a crucial resource for protein sequence analysis and annotation.
    • The database's evolution and SWISS-PROT integration ensure its continued relevance.
    • PROSITE's methods are integral to understanding protein function and evolution.