Related Experiment Videos
High-quality protein knowledge resource: SWISS-PROT and TrEMBL
Claire O'Donovan1, Maria Jesus Martin, Alexandre Gattiker
1EMBL Outstation, European Bioinformatics Institute, Hinxton, Cambridge, UK. odonovan@ebi.ac.uk
Briefings in Bioinformatics
|September 17, 2002
Summary
SWISS-PROT is a high-quality, curated protein sequence database offering detailed functional annotations. It integrates with other databases and, with its supplement TrEMBL, provides a comprehensive view of protein knowledge.
Area of Science:
- Bioinformatics
- Proteomics
- Molecular Biology
Background:
- SWISS-PROT is a vital protein sequence database known for its high-quality annotations.
- It aims to minimize redundancy and integrate with other biological databases.
Purpose of the Study:
- To describe the features and ongoing developments of the SWISS-PROT database.
- To highlight its role in providing comprehensive protein information alongside its supplement, TrEMBL.
Main Methods:
- Curated protein sequence data.
- Automatic annotation processes for TrEMBL.
- Database integration strategies.
Main Results:
- SWISS-PROT provides detailed functional annotations, including protein function, domain structure, and post-translational modifications.
- The combined SWISS-PROT and TrEMBL databases offer a comprehensive view of protein knowledge.
- Ongoing developments focus on improving annotation quality and expanding coverage for specific proteomes.
Conclusions:
- SWISS-PROT and TrEMBL are essential resources for protein research.
- Continuous improvements enhance the utility and scope of these protein databases.
- New resources like IPI and XML formats are being developed for user accessibility.